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公开(公告)号:US4965282A
公开(公告)日:1990-10-23
申请号:US501898
申请日:1990-03-30
申请人: Norio Takamura , Isao Inoue , Masaru Inage , Isao Yamaguchi , Koji Yano
发明人: Norio Takamura , Isao Inoue , Masaru Inage , Isao Yamaguchi , Koji Yano
IPC分类号: C07D231/12 , A61K31/415 , A61K31/44 , A61K31/443 , A61P7/10 , C07D231/16 , C07D405/06 , C07D405/14
CPC分类号: C07D405/14 , C07D405/06 , Y10S514/869
摘要: Novel benzodioxole derivative of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group, a lower alkoxy-lower alkyl group, phenyl group or pyridyl group, R.sup.2 is hydrogen atom or a halogen atom and R.sup.3 is hydrogen atom or a lower alkyl group, and a salt thereof are disclosed.Said derivative (I) and a salt thereof have potent diuretic, saluretic and uricosuric activities.
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公开(公告)号:US4973600A
公开(公告)日:1990-11-27
申请号:US304252
申请日:1989-01-31
申请人: Norio Takamura , Isao Inoue , Masaru Inage , Isao Yamaguchi
发明人: Norio Takamura , Isao Inoue , Masaru Inage , Isao Yamaguchi
IPC分类号: C07D231/12 , A61K31/415 , A61K31/44 , A61K31/443 , A61P7/10 , C07D231/16 , C07D405/06 , C07D405/14
CPC分类号: C07D405/14 , C07D405/06 , Y10S514/869
摘要: Novel benzodioxole derivative of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group, a lower alkoxy-lower alkyl group, phenyl group or pyridyl group, R.sup.2 is hydrogen atom or a halogen atom and R.sup.3 is hydrogen atom or a lower alkyl group, and a salt thereof are disclosed.Said derivative (I) and a salt thereof have potent diuretic, saluretic and uricosuric activities.
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公开(公告)号:US4853404A
公开(公告)日:1989-08-01
申请号:US105173
申请日:1987-10-05
申请人: Norio Takamura , Kuniyuki Oda , Shinichi Kodato , Isao Yamaguchi , Koji Yano
发明人: Norio Takamura , Kuniyuki Oda , Shinichi Kodato , Isao Yamaguchi , Koji Yano
IPC分类号: A61K31/415 , A61P3/12 , A61P7/10 , A61P19/06 , C07D231/12 , C07D231/14 , C07D231/16
CPC分类号: C07D231/12
摘要: Novel phenoxyacetic acid derivatives of the formula: ##STR1## wherein A is a substituted or unsubstituted 5-pyrazolyl group, R.sup.1 is hydrogen atom or a lower alkyl group, R.sup.2 is hydrogen atom or a lower alkenyl group, X is a halogen atom and Z is oxygen atom or methylene group, and salts thereof have potent diuretic, saluretic and uricosuric activities.
摘要翻译: 下式的新型苯氧基乙酸衍生物:其中A是取代或未取代的5-吡唑基,R 1是氢原子或低级烷基,R 2是氢原子或低级烯基,X 是卤素原子,Z是氧原子或亚甲基,及其盐。 所述衍生物(I)及其盐具有有效的利尿,盐析和尿酸活性。
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