公开(公告)号：US20080091357A1

公开(公告)日：2008-04-17

申请号：US11546608

申请日：2006-10-12

申请人： Noriyuki Sasaki ,  Rene Castro

发明人： Noriyuki Sasaki ,  Rene Castro

IPC分类号： G06F19/00

CPC分类号： G01N33/6878 ,  G01N2333/70539

摘要： The present invention is directed to methods, computer software and assay kits to identify epitopes, such as HLA epitopes. The preferred method comprises steps of constructing data tables of possible polymorphic sites of epitopes defined by a single antigen product, such as single antigen beads and, for a given string of specificities, searching the data table and presenting a list of possible single residues to explain the reactions. The methods, assay kits and computer software disclosed herein may also include an option for users to specify which positions or which paired positions to exclude and other parameters may be used to reduce the number of possible epitopes. In addition a graphical interface, such as a three-dimensional graph, may be included to permit easier selection from the multiple possibilities.

摘要翻译： 本发明涉及用于鉴定表位的方法，计算机软件和测定试剂盒，例如HLA表位。 优选的方法包括以下步骤：构建由单个抗原产物（例如单个抗原珠）定义的表位的可能多态性位点的数据表，并且对于给定的特异性特征，搜索数据表并呈现可能的单个残基的列表以解释 反应。 本文公开的方法，测定试剂盒和计算机软件还可以包括用于指定要排除哪些位置或哪个配对位置以及可以使用其它参数来减少可能的表位的数量的选项。 此外，可以包括诸如三维图形的图形界面以允许从多种可能性中更容易地进行选择。