公开(公告)号：US20240115581A1

公开(公告)日：2024-04-11

申请号：US17951747

申请日：2022-09-23

Applicant: Norwegian University of Science and Technology (NTNU)

Inventor： Christiana Bjorkli ,  Mary Hemler ,  Joshua Julian ,  Axel Sandvig ,  Ioanna Sandvig

IPC: A61K31/551 ,  A61K31/4545 ,  A61K49/00 ,  A61P25/28

CPC classification number: A61K31/551 ,  A61K31/4545 ,  A61K49/0008 ,  A61P25/28

Abstract: The present invention relates to products and methods for the treatment and/or prevention of neurological disorders characterized by neurodegeneration. More particularly, the invention provides a product comprising: (i) a Rho-associated protein kinase (ROCK) inhibitor (e.g. fasudil) or a pharmaceutically acceptable salt thereof; and (ii) a farnesyltransferase inhibitor (e.g. lonafarnib) or a pharmaceutically acceptable salt thereof; for use in treating or preventing a neurological disorder characterized by neurodegeneration in a subject.