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    METHOD FOR TREATMENT OF CYTOKINE RELEASE SYNDROME
    1.
    发明公开
    METHOD FOR TREATMENT OF CYTOKINE RELEASE SYNDROME 审中-公开

    公开(公告)号：US20240082240A1

    公开(公告)日：2024-03-14

    申请号：US18385686

    申请日：2023-10-31

    Applicant: NOVMETAPHARMA CO, LTD.

    Inventor： In-Kyu LEE ,  Jae-Han JEON ,  Dipanjan CHANDA ,  Eun Jung CHOI ,  Hoe Yune JUNG ,  Heon Jong LEE

    IPC: A61K31/495

    CPC classification number: A61K31/495

    Abstract: A composition for preventing and/or treating cytokine release syndrome and a method of prevention and/or treatment of cytokine release syndrome are disclosed. The composition includes an aryl ethene compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, as an active ingredient. The method includes administering the aryl ethene compound, an isomer, a pharmaceutically acceptable salt thereof, or a solvate thereof, in an effective amount to a subject in need thereof. The cytokine release syndrome may be caused by virulent infection. The administration of the compound reduces the pre-inflammatory cytokine levels in the subject.

    METHOD FOR TREATING INFLAMMATORY BOWEL DISEASES
    3.
    发明申请
    METHOD FOR TREATING INFLAMMATORY BOWEL DISEASES 有权

    公开(公告)号：US20220054541A1

    公开(公告)日：2022-02-24

    申请号：US17406626

    申请日：2021-08-19

    Applicant: NovMetaPharma Co., Ltd.

    Inventor： Hoe Yune JUNG

    IPC: A61K33/30 ,  A61P1/12

    Abstract: A new use of a cyclo(His-Pro) is disclosed. In particular, a method for treating inflammatory bowel disease which includes administering an effective amount of an isolated cyclo(His-Pro) or a pharmaceutically acceptable salt thereof to a subject in need thereof is disclosed.

    PROCESS FOR PREPARING ARYL ETHENE COMPOUND
    6.
    发明申请
    PROCESS FOR PREPARING ARYL ETHENE COMPOUND 有权

    公开(公告)号：US20250011267A1

    公开(公告)日：2025-01-09

    申请号：US18712003

    申请日：2022-11-22

    Applicant: NovMetaPharma Co., Ltd.

    Inventor： Hoe Yune JUNG ,  Heonjong LEE

    IPC: C07C39/23

    Abstract: Provided is a process for preparing an aryl ethene compound of formula (1) having high purity with high yield via a simple process. Also, disclosed is a process for preparing a dihydrochloride salt of the compound of formula (1), containing the step of reacting the compound of formula (1) with hydrogen chloride.

    PEG-MODIFIED CYCLIC DIPEPTIDES
    9.
    发明公开
    PEG-MODIFIED CYCLIC DIPEPTIDES 审中-公开

    公开(公告)号：US20240140955A1

    公开(公告)日：2024-05-02

    申请号：US18476630

    申请日：2023-09-28

    Applicant: NOVMETAPHARMA CO., LTD.

    Inventor： Heon Jong LEE ,  Hoe Yune JUNG

    IPC: C07D487/06

    CPC classification number: C07D487/06

    Abstract: Novel PEG modified cyclic dipeptide compounds are disclosed. The modified cyclic dipeptide compounds contain a cyclic dipeptide and a biocompatible polymer attached to the cyclic dipeptide. The cyclic dipeptide may be proline-containing, hydroxyproline-, or histidine-containing cyclic dipeptide. In one embodiment, the cyclic dipeptide is a cyclo (-his-pro). Exemplary modified cyclic dipeptide compounds are represented by Formula A′:

    USE OF CYCLO-HISPRO (CHP) FOR LOWERING BLOOD PRESSURE
    10.
    发明公开
    USE OF CYCLO-HISPRO (CHP) FOR LOWERING BLOOD PRESSURE 审中-公开

    公开(公告)号：US20230165855A1

    公开(公告)日：2023-06-01

    申请号：US17912942

    申请日：2021-03-19

    Applicant: NOVMETAPHARMA CO., LTD. ,  SEOUL NATIONAL UNIVERSITY HOSPITAL ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

    Inventor： Hoe Yune JUNG ,  Heon Jong LEE ,  Yon Su KIM ,  Seung Hee YANG

    IPC: A61K31/4985 ,  A61P9/12

    CPC classification number: A61K31/4985 ,  A61P9/12

    Abstract: New uses of Cyclo-HisPro (CHP) or a salt thereof for lowering blood pressure are disclosed. More specifically, the present invention relates to a pharmaceutical composition for lowering blood pressure, containing CHP or a salt thereof, and a functional health food composition containing CHP or a salt thereof; a method for lowering blood pressure using CHP or a salt thereof; a use of CHP or a salt thereof in the manufacture of antihypertensive agents; a pharmaceutical composition or a functional health food, for preventing or treating hypertension or complications thereof, containing CHP or a salt thereof; a method for preventing or treating hypertension or complications thereof by using CHP or a salt thereof; and a use of CHP or a salt thereof in the manufacture of a medicament for preventing or treating hypertension or complications thereof.

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