公开(公告)号：US20220409581A1

公开(公告)日：2022-12-29

申请号：US17776273

申请日：2020-11-13

Applicant: Nova Southeastern University

Inventor： Appu RATHINAVELU ,  Thiagarajan VENKATESAN ,  Jayanta K. DAS ,  Mohammad Mansour S. ALGAHTANI

IPC: A61K31/4035 ,  A61K31/495 ,  A61K39/395 ,  A61P35/00

Abstract: The invention provides methods for using F16 isoindole small molecules for treatment of solid tumors, particularly brain cancers, such as glioblastoma multiforme (GBM). F16 isoindole is an inhibitor of angiogenesis and is capable of antagonizing tumor vasculature. The invention also provides pharmaceutical compositions including F16 isoindole small molecules.