公开(公告)号：US09040559B2

公开(公告)日：2015-05-26

申请号：US14450692

申请日：2014-08-04

Applicant: Novartis AG

Inventor： Bernard Cuenoud ,  Ian Bruce ,  Robin Alec Fairhurst ,  David Beattie

IPC: A61K31/395 ,  A61K31/4709 ,  C07C215/80 ,  C07C233/43 ,  C07C311/08 ,  C07D215/227 ,  C07D215/26 ,  C07D405/12 ,  A61K45/06

CPC classification number: A61K31/4709 ,  A61K45/06 ,  C07C215/80 ,  C07C233/43 ,  C07C311/08 ,  C07C2602/08 ,  C07D215/227 ,  C07D215/26 ,  C07D405/12

Abstract: Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.

Abstract translation: 其中Ar为式Y的化合物为碳或氮，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，X，n，p， q和r如说明书中所定义，它们的制备及其作为药物的用途，特别是用于治疗阻塞性或炎症性气道疾病。