公开(公告)号：US20220184074A1

公开(公告)日：2022-06-16

申请号：US17612778

申请日：2020-05-20

申请人： NOVARTIS AG

发明人： Souvik BHATTACHARYA ,  Bruno BIETH ,  Maciej CABANSKI ,  Bruno CENNI ,  Stefan DE BUCK ,  Martin KAUL ,  Arvind KINHIKAR ,  Andrijana RADIVOJEVIC ,  Thomas SEVERIN ,  Julian STORIM ,  Alessandra VITALITI GARAMI

IPC分类号： A61K31/505 ,  A61P17/00

摘要： The present disclosure relates to methods for treating Chronic Spontaneous Urticaria using a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Also disclosed herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, for treating Chronic Spontaneous Urticaria patients, as well as medicaments, dosing regimens, pharmaceutical formulations, dosage forms, and kits for use in the disclosed uses and methods.

公开(公告)号：US20240350489A1

公开(公告)日：2024-10-24

申请号：US18685551

申请日：2022-09-01

申请人： NOVARTIS AG

发明人： Souvik BHATTACHARYA ,  Bruno BIETH ,  Bruno CENNI ,  Peter END ,  Gordon GRAHAM ,  Michael JUHNKE ,  Rajesh Singh KARAN ,  Allison Donna MANN ,  Etienne PIGEOLET ,  Karin RAPP ,  Kim-Hien SIN ,  Huixin YU ,  Ying ZHANG

IPC分类号： A61K31/505 ,  A61K9/20 ,  A61K9/48 ,  A61P25/28

CPC分类号： A61K31/505 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/4858 ,  A61K9/4866 ,  A61P25/28

摘要： The invention concerns method of treating multiple sclerosis (MS) by administering a therapeutically effective dose of LOU064 or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20190038628A1

公开(公告)日：2019-02-07

申请号：US16075066

申请日：2017-02-10

申请人： Novartis AG

发明人： Bruno BIETH ,  Christoph BURKHART ,  Andreas CHRIST ,  Stefan DE BUCK ,  Christoph KALIS ,  Sam LINDGREN

IPC分类号： A61K31/519 ,  A61P37/00

摘要： The invention relates to the use of 1-{(S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidin-1-yl}-propan-1-one or pharmaceutically acceptable salts thereof for the treatment of primary Sjögren's Syndrome.

公开(公告)号：US20220175772A1

公开(公告)日：2022-06-09

申请号：US17612737

申请日：2020-05-20

申请人： NOVARTIS AG

发明人： Souvik BHATTACHARYA ,  Bruno BIETH ,  Maciej CABANSKI ,  Bruno CENNI ,  Stefan DE BUCK ,  Martin KAUL ,  Arvind KINHIKAR ,  Andrijana RADIVOJEVIC ,  Alessandra VITALITI GARAMI

IPC分类号： A61K31/505 ,  A61P37/06 ,  A61P1/02

摘要： The present disclosure relates to methods for treating Sjögren's Syndrome disease using a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Also disclosed herein a compound of Formula (I) or a pharmaceutically acceptable salt thereof, for treating Sjögren's Syndrome patients, as well as medicaments, dosing regimens, pharmaceutical formulations, dosage forms, and kits for use in the disclosed uses and methods.