公开(公告)号：US20210355115A1

公开(公告)日：2021-11-18

申请号：US17278163

申请日：2019-09-19

Applicant: Novartis AG

Inventor： Rohan Eric John Beckwith ,  Hua Jiang ,  Ce Wang

IPC: C07D413/14 ,  A61P27/16

Abstract: A compound of Formula (I) or or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating hearing loss or balance disorder: Formula (I) wherein R1 and Y are as defined herein.

公开(公告)号：US11420970B1

公开(公告)日：2022-08-23

申请号：US17327226

申请日：2021-05-21

Applicant: NOVARTIS AG

Inventor： Haibing Deng ,  Jinbiao Liu ,  Counde Oyang ,  Ce Wang ,  Qitao Xiao ,  Guoliang Xun ,  Haiqiang Zeng

IPC: C07D473/34

Abstract: The present invention provides a compound of Formula (I): or an enantiomer, an enantiomeric mixture, or a pharmaceutically acceptable salt thereof; wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating a disease or condition mediated by nuclear SET domain-containing protein 2 (NSD2).