公开(公告)号：US20230321067A1

公开(公告)日：2023-10-12

申请号：US18000165

申请日：2021-06-21

Applicant: Novartis AG

Inventor： Eva Marie Genevieve D'HENNEZEL ,  Yi GU ,  Lisa Marie KATTENHORN ,  Fariba KHANSHAN ,  Eunice Lee KWAK ,  Joanne Choi RANDOLPH ,  Christopher Sean STRAUB

IPC: A61K31/4545 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K31/4545 ,  A61K45/06 ,  A61P35/00

Abstract: The present disclosure relates to dosing regimens comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione compounds or pharmaceutical compositions, pharmaceutical formulations, or combinations comprising the same; and methods of using such compounds, combinations, and compositions in the treatment or prevention IKAROS Family Zinc Finger 2 (IKZF2)-dependent diseases or disorders or where reduction of IKZF2 or IKZF4 protein levels can ameliorate a disease, for example, the treatment of cancers.