公开(公告)号：US08865894B2

公开(公告)日：2014-10-21

申请号：US13773947

申请日：2013-02-22

Applicant: Novartis AG

Inventor： Giorgio Caravatti ,  Robin Alec Fairhurst ,  Pascal Furet ,  Frédéric Stauffer ,  Frank Hans Seiler ,  Clive McCarthy ,  Heinrich Rueeger

IPC: C07D401/14 ,  A01N43/54 ,  C07D403/04 ,  C07D413/14 ,  A61K31/5377 ,  A61K45/06

CPC classification number: C07D498/04 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/14

Abstract: The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.

Abstract translation: 本发明涉及作为PI3K（磷脂酰肌醇-3-激酶）抑制剂的恶唑烷-2-酮取代的嘧啶化合物及其药物组合物，其制备方法和用于治疗依赖于 PI3K。