公开(公告)号：US20190381011A1

公开(公告)日：2019-12-19

申请号：US16230033

申请日：2018-12-21

Applicant: Novartis AG

Inventor： Kamlesh Jagdis BALA ,  Andrew BREARLEY ,  James DALE ,  Anne-Marie EDWARDS ,  Mahbub AHMED ,  David PORTER ,  Robert Alexander PULZ ,  Lisa Ann ROONEY ,  David Andrew SANDHAM ,  Duncan SHAW ,  Nichola SMITH ,  Jessica Louise TAYLOR ,  Roger John TAYLOR ,  Thomas Josef Troxler ,  Joe WRIGGLESWORTH

IPC: A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20210052554A1

公开(公告)日：2021-02-25

申请号：US17089064

申请日：2020-11-04

Applicant: Novartis AG

Inventor： Kamlesh Jagdis BALA ,  Andrew BREARLEY ,  James DALE ,  Anne-Marie EDWARDS ,  Mahbub AHMED ,  David PORTER ,  Robert Alexander PULZ ,  Lisa Ann ROONEY ,  David Andrew SANDHAM ,  Duncan SHAW ,  Nichola SMITH ,  Jessica Louise TAYLOR ,  Roger John TAYLOR ,  Thomas Josef Troxler ,  Joe WRIGGLESWORTH

IPC: A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20230301970A1

公开(公告)日：2023-09-28

申请号：US18317990

申请日：2023-05-16

Applicant: Novartis AG

Inventor： Kamlesh Jagdis BALA ,  Andrew BREARLEY ,  James DALE ,  Anne-Marie EDWARDS ,  Mahbub AHMED ,  David PORTER ,  Robert Alexander PULZ ,  Lisa Ann ROONEY ,  David Andrew SANDHAM ,  Duncan SHAW ,  Nichola SMITH ,  Jessica Louise TAYLOR ,  Roger John TAYLOR ,  Thomas Josef TROXLER-SCHWAB ,  Joe WRIGGLESWORTH

IPC: A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

CPC classification number: A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

Abstract: The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof;




a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20200268718A1

公开(公告)日：2020-08-27

申请号：US16874595

申请日：2020-05-14

Applicant: Novartis AG

Inventor： Kamlesh Jagdis BALA ,  Andrew BREARLEY ,  James DALE ,  Anne-Marie EDWARDS ,  Mahbub AHMED ,  David PORTER ,  Robert Alexander PULZ ,  Lisa Ann ROONEY ,  David Andrew SANDHAM ,  Duncan SHAW ,  Nichola SMITH ,  Jessica Louise TAYLOR ,  Roger John TAYLOR ,  Thomas Josef TROXLER ,  Joe WRIGGLESWORTH

IPC: A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20170014388A1

公开(公告)日：2017-01-19

申请号：US15184730

申请日：2016-06-16

Applicant: Novartis AG

Inventor： Kamlesh Jagdis BALA ,  Andrew BREARLEY ,  James DALE ,  Anne-Marie EDWARDS ,  Mahbub AHMED ,  David PORTER ,  Robert Alexander PULZ ,  Lisa Ann ROONEY ,  David Andrew SANDHAM ,  Duncan SHAW ,  Nichola SMITH ,  Jessica Louise TAYLOR ,  Roger John TAYLOR ,  Thomas Josef Troxler ,  Joe WRIGGLESWORTH

IPC: A61K31/422

CPC classification number: A61K31/422 ,  A61K31/4155 ,  C07D413/12 ,  C07D413/14 ,  A61K2300/00

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract translation: 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。