公开(公告)号：US20240245670A1

公开(公告)日：2024-07-25

申请号：US17415923

申请日：2019-12-19

申请人： Novartis AG

发明人： Simone BONAZZI ,  Adam Crystal ,  John Scott Cameron ,  Eva Marie Genevieve D'Hennezel ,  Glenn Dranoff ,  Ry Roger Forseth ,  Dominik Johannes Hainzl ,  Jacqueline Kinyamu-Akunda ,  Guiqing Liang ,  Lilly Mary Petruzzelli

IPC分类号： A61K31/4545 ,  A61K9/00 ,  A61K31/55 ,  A61P35/00

CPC分类号： A61K31/4545 ,  A61K9/0053 ,  A61K31/55 ,  A61P35/00

摘要： The present disclosure relates to dosing regimens, formulations, and combinations comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione compounds or pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention IKAROS Family Zinc Finger 2 (IKZF2)-dependent diseases or disorders or where reduction of IKZF2 or IKZF4 protein levels can ameliorate a disease, for example, the treatment of cancers.