公开(公告)号：US20190002393A1

公开(公告)日：2019-01-03

申请号：US16135116

申请日：2018-09-19

Applicant: Novartis AG

Inventor： Rohan Eric John BECKWITH ,  Luis BRITO ,  Brian Addison DECHRISTOPHER ,  Gabriel Grant GAMBER ,  Andrew GEALL ,  Thomas ZABAWA

IPC: C07C219/06 ,  C07D211/34 ,  A61K47/18 ,  C07D207/08 ,  C07C217/58 ,  C07C219/16 ,  C07D211/62 ,  C07C229/12 ,  A61K31/713 ,  A61K31/711 ,  A61K31/7105 ,  A61K9/51 ,  A61K9/127 ,  A61K47/22 ,  C07D295/15

Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein RA, RB, R2 and R4 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

公开(公告)号：US20170275243A1

公开(公告)日：2017-09-28

申请号：US15505282

申请日：2015-09-04

Applicant: Novartis AG

Inventor： Rohan Eric John BECKWITH ,  Luis BRITO ,  Brian Addison DECHRISTOPHER ,  Gabriel Grant GAMBER ,  Andrew GEALL ,  Thomas ZABAWA

IPC: C07C219/06 ,  A61K9/127 ,  C07D295/15 ,  C07C219/16 ,  C07C229/12 ,  C07D207/08 ,  A61K47/22 ,  C07C217/58

CPC classification number: C07C219/06 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K47/18 ,  A61K47/22 ,  C07C217/58 ,  C07C219/16 ,  C07C229/12 ,  C07D207/08 ,  C07D211/34 ,  C07D211/62 ,  C07D295/15

Abstract: This invention provides for a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein RA, RB, R2 and R4 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.