公开(公告)号：US20200289514A1

公开(公告)日：2020-09-17

申请号：US15775060

申请日：2016-11-11

Applicant: Novartis AG

Inventor： Karen KAMMERTOENS ,  Jean QUANCARD ,  Achim SCHLAPBACH ,  Oliver SIMIC ,  Marina TINTELNOT-BLOMLEY ,  Grahame WOOLLAM

IPC: A61K31/519 ,  A61K45/06 ,  C07D487/04

Abstract: The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.