公开(公告)号：US08759517B2

公开(公告)日：2014-06-24

申请号：US13624320

申请日：2012-09-21

Applicant: Novartis AG

Inventor： Guido Bold ,  Pascal Furet ,  Vito Guagnano

IPC: C07D239/48

CPC classification number: C07D239/48 ,  C07D401/12

Abstract: The invention relates to heteroaryl aryl ureas of the formula IA, wherein the radicals and symbols have the meanings as defined herein, the use of such compounds in the treatment of protein kinase dependent diseases; to pharmaceutical preparations comprising said heteroaryl aryl ureas, to processes for the manufacture of such novel compounds and to methods of treatment comprising the use of such heteroaryl aryl ureas.

Abstract translation: 本发明涉及式IA的杂芳基芳基脲，其中基团和符号具有本文定义的含义，这些化合物在治疗蛋白激酶依赖性疾病中的用途; 涉及包含所述杂芳基芳基脲的药物制剂，以及制备这些新化合物的方法和包括使用这种杂芳基芳基脲的治疗方法。

公开(公告)号：US20130030171A1

公开(公告)日：2013-01-31

申请号：US13624320

申请日：2012-09-21

Applicant: Novartis AG

Inventor： Guido Bold ,  Pascal Furet ,  Vito Guagnano

IPC: C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D413/12 ,  C07D239/48

CPC classification number: C07D239/48 ,  C07D401/12

Abstract: The invention relates to heteroaryl aryl ureas of the formula IA, wherein the radicals and symbols have the meanings as defined herein, the use of such compounds in the treatment of protein kinase dependent diseases; to pharmaceutical preparations comprising said heteroaryl aryl ureas, to processes for the manufacture of such novel compounds and to methods of treatment comprising the use of such heteroaryl aryl ureas.

Abstract translation: 本发明涉及式IA的杂芳基芳基脲，其中基团和符号具有本文定义的含义，这些化合物在治疗蛋白激酶依赖性疾病中的用途; 涉及包含所述杂芳基芳基脲的药物制剂，以及制备这些新化合物的方法和包括使用这种杂芳基芳基脲的治疗方法。