公开(公告)号：US20230374029A1

公开(公告)日：2023-11-23

申请号：US18004313

申请日：2021-07-06

申请人： Novartis AG

发明人： Zhongbo FEI ,  Huanqing JIA ,  Wei LI ,  Jianhua WANG ,  Huangchao YU

IPC分类号： C07D491/107

CPC分类号： C07D491/107

摘要： The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention, said manufacture including the manufacture and use of a compound of the formula VI; wherein R1 is a secondary amino protecting group and R5 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted aryl.