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公开(公告)号:US12209144B2
公开(公告)日:2025-01-28
申请号:US17296679
申请日:2019-11-26
Applicant: Novartis AG
Inventor: Alec Nathanson Flyer , Andrei Alexandrovich Golosov , Philipp Grosche , Ian Lewis , Eugene Yuejin Liu , Andreas Marzinzik , Lauren Gilchrist Monovich , Johannes Ottl , Tajesh Jayprakash Patel , Patrick Crawford Reid , Mohindra Seepersaud
Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein R1, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, and X13 are described herein.