公开(公告)号：US20220251067A1

公开(公告)日：2022-08-11

申请号：US17574820

申请日：2022-01-13

Applicant: Novartis AG

Inventor： Christopher FARADY ,  Nina GOMMERMANN ,  Philipp JANSER ,  Angela MACKAY ,  Henri MATTES ,  Nichola SMITH ,  Catherine Fooks SOLOVAY ,  Nikolaus Johannes STIEFL ,  Eric VANGREVELINGHE ,  Juraj VELCICKY ,  Anette von MATT

IPC: C07D401/12 ,  C07D237/14 ,  C07D237/20 ,  C07D403/12 ,  C07D413/12 ,  C07D451/04

Abstract: The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.

公开(公告)号：US20210308140A1

公开(公告)日：2021-10-07

申请号：US17259252

申请日：2019-07-23

Applicant: Novartis AG

Inventor： Christopher FARADY ,  Nina GOMMERMANN ,  Philipp JANSER ,  Angela MACKAY ,  Henri MATTES ,  Nikolaus Johannes STIEFL ,  Juraj VELCICKY

IPC: A61K31/53 ,  A61K45/06 ,  A61K31/616 ,  C07D495/14 ,  C07D513/14

Abstract: The present invention relates to novel thienopyrrolotriazinacetamide compounds of Formula (I): wherein R1, R2 and R3 are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of disease and disorders mediated by NLRP3.