公开(公告)号：US20250090699A1

公开(公告)日：2025-03-20

申请号：US18802972

申请日：2024-08-13

Applicant: Novartis AG

Inventor： Salvatore BONGARZONE ,  Davide CAMPORESE ,  Gonçalo dos Santos CLEMENTE ,  Takeru EHARA ,  Matteo FISCHER ,  Andrei Alexandrovich GOLOSOV ,  Philipp GROSCHE ,  Philipp HOLZER ,  Alexei KARPOV ,  Marion LACAUD-BAUMLIN ,  Lukas LEDER ,  Rafael Bermeo MALO ,  Andreas MARZINZIK ,  Yoshihide MIZUKOSHI ,  Charlie MUNSCH ,  Markus Oliver RESCHKE ,  Holger SELLNER ,  Therese-Marie STACHYRA

IPC: A61K51/08 ,  A61P35/00 ,  C07B59/00

Abstract: Described herein are cyclic peptides targeting fibroblast activation protein (FAP), and their incorporation into compounds for radioligand imaging and therapies, as well as methods and/or uses of such compounds for the imaging, treatment and/or prevention of FAP-implicated diseases and disorders.