公开(公告)号：US20230286924A1

公开(公告)日：2023-09-14

申请号：US18040552

申请日：2021-08-04

Applicant: Novartis AG

Inventor： Michael MUTZ ,  Fang WANG ,  Mei XIA

IPC: C07D239/91 ,  A61K9/08 ,  A61K31/517 ,  A61K9/00

CPC classification number: C07D239/91 ,  A61K9/08 ,  A61K31/517 ,  A61K9/0048 ,  C07B2200/13

Abstract: The present disclosure provides polymorphs and formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present disclosure further provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides 5 methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.