公开(公告)号：US20230181756A1

公开(公告)日：2023-06-15

申请号：US17997137

申请日：2021-04-11

Applicant: Novartis AG

Inventor： Vasileios ASKOXYLAKIS ,  Michelle COULSON ,  Anhthu DANG ,  Yuyan DUAN ,  Jessica MAKOFSKE ,  Sabine ROTTMANN ,  Xiaoli WANG

IPC: A61K47/68 ,  A61K45/06 ,  C07K16/28 ,  A61K9/00 ,  A61P35/00 ,  A61K38/12

CPC classification number: A61K47/6867 ,  A61K45/06 ,  C07K16/2866 ,  A61K9/0019 ,  A61P35/00 ,  A61K38/12

Abstract: This application discloses compositions and methods of treating follicular lymphoma using CCR7 antibody drug conjugates. Also disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to said subject an antibody drug conjugate, wherein the cancer expresses CCR7, wherein the antibody drug conjugate is administered to said subject at about 0.1 mg/kg to about 10 mg/kg.