公开(公告)号：US10077317B2

公开(公告)日：2018-09-18

申请号：US14280017

申请日：2014-05-16

Applicant: Novartis AG

Inventor： Andrew Paul Garner ,  Elizabeth Anne Reisinger Sprague ,  Seth Alexander Ettenberg ,  Christian Kunz ,  Nicole Haubst ,  Winfried Elis

IPC: C07K16/30 ,  C07K16/32 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/32 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: The present invention relates to antibodies or fragments thereof that target a conformational epitope of a HER receptor. In particular, the invention relates to antibodies or fragments thereof that target a conformational epitope of HER3 receptor and compositions and methods of use thereof.