公开(公告)号：US10906930B2

公开(公告)日：2021-02-02

申请号：US15771286

申请日：2016-10-28

Applicant: ADURO BIOTECH, INC. ,  NOVARTIS AG

Inventor： George Edwin Katibah ,  David Kanne ,  Leonard Sung ,  Kelsey Gauthier ,  Laura Hix Glickman ,  Justin Leong ,  Sarah M. McWhirter ,  Thomas W. Dubensky, Jr. ,  Jeffrey McKenna ,  Stephen M. Canham ,  Chudi Obioma Ndubaku

IPC: C07H21/04 ,  A61K39/39 ,  C07H21/02 ,  A61K39/12 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

Abstract: The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′- or 3′-mono-fluoro substituted, or 2′3′-di-fluoro substituted mixed linkage 2′,5′-3′,5′ CDNs.

公开(公告)号：US20220152150A1

公开(公告)日：2022-05-19

申请号：US17433812

申请日：2020-02-24

Applicant: Novartis AG

Inventor： Sandeep Tharian Koshy ,  Stephen M. Canham

IPC: A61K38/17 ,  A61K47/69 ,  A61K47/59 ,  A61K48/00 ,  A61K47/64 ,  A61K31/4745 ,  C12N5/0783 ,  C12N15/86

Abstract: The present invention relates generally to the use of compositions including mesoporous silica particles that may be surface modified, for the delivery of viral vectors. In some embodiments, the viral vectors are used to transduce T cells to express a chimeric antigen receptor (CAR), to treat a subject having a disease, e.g., a disease associated with expression of a tumor antigen.