公开(公告)号：US20190321295A1

公开(公告)日：2019-10-24

申请号：US16425990

申请日：2019-05-30

Applicant: Novartis AG

Inventor： Keith A. Bowman ,  Noah Gardner ,  Travis Jeannotte ,  Chandra Vargeese

IPC: A61K9/127 ,  A61K48/00 ,  A61K31/7105 ,  C12N15/113 ,  C12N15/88 ,  A61K31/713

Abstract: Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.

公开(公告)号：US10342761B2

公开(公告)日：2019-07-09

申请号：US15326291

申请日：2015-07-10

Applicant: Novartis AG

Inventor： Keith A. Bowman ,  Noah Gardner ,  Travis Jeannotte ,  Chandra Vargeese

IPC: A61K9/127 ,  C12N15/88 ,  C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  A61K48/00

Abstract: Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.