公开(公告)号：US20230365571A1

公开(公告)日：2023-11-16

申请号：US18044455

申请日：2021-09-15

Applicant: Novartis AG

Inventor： Trixi Brandl ,  Claus Ehrhardt ,  Robert Epple ,  Christian Markert ,  Pascal Rigollier ,  Juraj Velcicky

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to tricyclic compounds comprising a diazepinone moiety which are effective in inhibiting Sppl2a (signal peptide peptidase like protease 2a), to pharmaceutical compositions containing such inhibitors, and to methods of using such inhibitors and compositions.

公开(公告)号：US20130149281A1

公开(公告)日：2013-06-13

申请号：US13764509

申请日：2013-02-11

Applicant: NOVARTIS AG

Inventor： Trixi Brandl ,  Jiping Fu ,  Francois Lenoir ,  David Thomas Parker ,  Michael Patane ,  Branko Radetich ,  Prakash Raman ,  Pascal Rigollier ,  Mohindra Seepersaud ,  Oliver Simic ,  Aregahegn Yifru ,  Rui Zhang

IPC: A61K38/07 ,  A61K45/06 ,  A61K38/06

CPC classification number: A61K38/07 ,  A61K38/00 ,  A61K38/06 ,  A61K45/06 ,  C07D209/96 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/10 ,  C07D491/20 ,  C07D495/10 ,  C07D498/04 ,  C07D498/10 ,  C07K5/06034 ,  C07K5/06078 ,  C07K5/06165 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/101 ,  C07K5/1016

Abstract: The present application describes a method of treating an HCV-associated disorder by administering to a subject in need thereof a pharmaceutically effective amount of a compound of formula I in combination with an additional HCV-modulating compound.

Abstract translation: 本申请描述了通过向有需要的受试者施用药学有效量的式I化合物与另外的HCV调节化合物组合来治疗HCV相关疾病的方法。