公开(公告)号：US11066369B2

公开(公告)日：2021-07-20

申请号：US16566083

申请日：2019-09-10

Applicant: Novartis AG

Inventor： Mihai Azimioara ,  Bei Chen ,  Robert Epple ,  Ayako Honda ,  Philip Lam ,  Hasnain Ahmed Malik ,  Casey Jacob Nelson Mathison ,  True Ngoc Nguyen ,  Victor Ivanovich Nikulin ,  Sejal Patel ,  Dean Paul Phillips ,  Rodrigo A. Rodriguez ,  Baogen Wu ,  Xuefeng Zhu

IPC: C07D401/02 ,  C07D213/76 ,  C07D401/14 ,  A61K31/444 ,  C07D401/12 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D493/08

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.