公开(公告)号：US20200345746A1

公开(公告)日：2020-11-05

申请号：US16931783

申请日：2020-07-17

Applicant: Novartis AG

Inventor： Cristina LOPEZ-LOPEZ ,  Ulf NEUMANN

IPC: A61K31/5377

Abstract: The present invention relates to an oxazine derivative BACE-1 inhibitor and pharmaceutical compositions comprising such oxazine derivative for use in the prevention of Alzheimer's disease in a patient at risk of developing clinical symptoms of Alzheimer's disease, and in particular, wherein the patient at risk of developing clinical symptoms of Alzheimer's disease carries one or two copies of the ApoE4 allele.

公开(公告)号：US20200207830A1

公开(公告)日：2020-07-02

申请号：US16633797

申请日：2018-07-26

Applicant: NOVARTIS AG

Inventor： Dominik FEUERBACH ,  Ulf NEUMANN

IPC: C07K14/705 ,  C12N15/86 ,  C12N7/00

Abstract: Provided herein are methods and compositions related to TREM2 mutants resistant to sheddase cleavage, e.g., human TREM2 mutants resistant to sheddase cleavage, and nucleic acids encoding such TREM2 mutants resistant to sheddase cleavage.

公开(公告)号：US20180125853A1

公开(公告)日：2018-05-10

申请号：US15730175

申请日：2017-10-11

Applicant: Novartis AG

Inventor： Cristina LOPEZ-LOPEZ ,  Ulf NEUMANN ,  Derya SHIMSHEK

IPC: A61K31/5377 ,  A61P9/10

Abstract: The present invention relates to an oxazine derivative BACE-1 inhibitor and pharmaceutical compositions comprising such oxazine derivative for use in the treatment or prevention of cerebral amyloid angiopathy and, in particular, wherein the patient carries one or two copies of the ApoE4 allele.

公开(公告)号：US20180036315A1

公开(公告)日：2018-02-08

申请号：US15651845

申请日：2017-07-17

Applicant: Novartis AG

Inventor： Cristina LOPEZ-LOPEZ ,  Ulf NEUMANN

IPC: A61K31/5377

Abstract: The present invention relates to an oxazine derivative BACE-1 inhibitor and pharmaceutical compositions comprising such oxazine derivative for use in the prevention of Alzheimer's disease in a patient at risk of developing clinical symptoms of Alzheimer's disease, and in particular, wherein the patient at risk of developing clinical symptoms of Alzheimer's disease carries one or two copies of the ApoE4 allele.