公开(公告)号：US20230167100A1

公开(公告)日：2023-06-01

申请号：US17919490

申请日：2021-08-10

Applicant: Novartis AG

Inventor： Xuan DAI ,  Michael DORE ,  Xiang-Ju Justin GU ,  Ling LI ,  Kun Chin LIU ,  Sing Yeung Frankie MAK ,  Yuan MI ,  Counde OYANG ,  Julien PAPILLON ,  Wei (Vicky) QI ,  Xiaoxia YAN ,  Zhengtian YU ,  Ji Yue (Jeff) ZHANG ,  Kehao ZHAO

IPC: C07D405/14 ,  A61K45/06

CPC classification number: C07D405/14 ,  A61K45/06

Abstract: The invention disclosed herein relates to aza-quinoline compounds of Formula (I), pharmaceutical compositions comprising such compounds, and the use of such compounds for treating a disease or condition mediated by Enhancer of Zeste Homolog 2 (EZH2), Polycomb Repressive Complex 2 (PRC2), or a combination thereof.

公开(公告)号：US20220280509A1

公开(公告)日：2022-09-08

申请号：US17632990

申请日：2020-09-24

Applicant: Novartis AG

Inventor： Ling LI ,  Xuan DAI ,  Michael DORE ,  Xiang-Ju Justin GU ,  Kevin Kun Chin LIU ,  Sing Yeung Frankie MAK ,  Yuan MI ,  Counde OYANG ,  Julien PAPILLON ,  Wei (Vicky) QI ,  Xiaoxia YAN ,  Zhengtian YU ,  Ji Yue (Jeff) ZHANG ,  Kehao ZHAO

IPC: A61K31/506 ,  A61K45/06 ,  C07D471/04 ,  A61P35/00 ,  A61K31/5377 ,  A61K31/541

Abstract: Provided aza-quinoline compounds of Formula (I), pharmaceutical compositions comprising such compounds; and the use of such compounds for treating a disease or condition mediate by Enhancer of Zeste Homolog 2 (EZH2), Polycomb Repressive Complex 2 (PRC2), or a combination thereof.