公开(公告)号：US20190046533A1

公开(公告)日：2019-02-14

申请号：US15998710

申请日：2018-08-16

Applicant: Novartis AG

Inventor： Yan Chen ,  Xizhong Huang ,  Sunkyu Kim

IPC: A61K31/519 ,  A61K31/5685 ,  A61K31/551 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/5513 ,  A61K31/436 ,  A61K31/4196 ,  A61K31/565 ,  A61K31/138

Abstract: The present disclosure relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof. The present disclosure also relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof, (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof, and (3) a third agent which is an agent that regulates the PI3K/Akt/mTOR pathway or a pharmaceutically acceptable salt thereof.