专利检索 ap:("Novartis AG" OR "The Trustees of the University of Pennsylvania") AND inv:"Alfonso Quintas-Cardama" 第 1 页

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发明申请
COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS AND PD-1 INHIBITORS 审中-公开

公开(公告)号：US20190151365A1

公开(公告)日：2019-05-23

申请号：US16321322

申请日：2017-07-28

申请人： Novartis AG , The Trustees of the University of Pennsylvania

发明人： Oezlem Anak , Sanela Bilic , Jennifer Brogdon , John Scott Cameron , William Chou , Stephan Grupp , Danny Roland Howard, Jr. , Randi Isaacs , Carl H. June , Simon Lacey , Shannon Maude , Jan J. Melenhorst , Stephen Shuster , Alfonso Quintas-Cardama

IPC分类号： A61K35/17 , C07K14/725 , C07K16/28 , A61P35/00 , G01N33/574

摘要： Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.