公开(公告)号：US20140113970A1

公开(公告)日：2014-04-24

申请号：US13657711

申请日：2012-10-22

申请人： Nuvo Research Inc. ,  Mallinckrodt LLC

发明人： Tejas Desai ,  Ngoc Truc-Chi Vo ,  Brian Dean Doty ,  Ronald J. Brendel ,  Baohua Yue

IPC分类号： A61M35/00 ,  A61K31/196

CPC分类号： A61K31/196 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/08 ,  A61K47/38 ,  A61M35/003

摘要： The invention provides systems and methods for controlled dispensing of topical analgesics contained in a metered dispensing system. The systems and method are useful for treating signs and symptoms of osteoarthritis. The method includes depressing a hand pump to dispense a dose of a topical pain reliever in a viscous solution from the hand pump, wherein the hand pump is configured to dispense the dose within a tolerance specified by a corresponding label approved by a government regulatory agency; and spreading the topical solution on skin.

摘要翻译： 本发明提供了用于受控分配包含在计量分配系统中的局部止痛剂的系统和方法。 该系统和方法可用于治疗骨关节炎的体征和症状。 该方法包括按压手泵以将来自手动泵的粘性溶液中的一定剂量的局部止痛剂分配到其中，其中手动泵配置为在由政府监管机构批准的对应标签指定的容限内分配剂量; 并将局部溶液涂抹在皮肤上。

公开(公告)号：US20180344644A1

公开(公告)日：2018-12-06

申请号：US15761676

申请日：2016-09-21

申请人： Mallinckrodt LLC

发明人： Satheesh Podaralla ,  Tsz Chung Lai ,  Baohua Yue

IPC分类号： A61K9/127 ,  A61K31/337 ,  A61K31/496 ,  A61K9/00 ,  A61P35/02

CPC分类号： A61K9/1272 ,  A61K9/0019 ,  A61K9/1277 ,  A61K31/337

摘要： The present invention provides improved stable liposomal formulations and method of preparation thereof. The liposomal formulations include liposomes containing a phosphatidylcholine lipid, a sterol, a PEG-lipid, and a taxane, wherein the taxane is docetaxel or a derivative thereof. The liposomal formulations have improved stability and extended shelf-life. The present invention also provides pharmaceutical compositions comprising a liposomal formulation for the treatment of cancer.