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公开(公告)号：US11191833B2
公开(公告)日：2021-12-07
申请号：US16308356
申请日：2017-06-12
申请人： OCTAPHARMA AG
发明人： Karin Ahrer , Waltraud Kaar , Ulrich Roessl
摘要： The present invention relates to a liquid composition comprising polyclonal immunoglobulins, at least one viscosity modulating amino acid, selected from arginine and histidine, and at least one stabilising amino acid, selected from glycine and proline, wherein more than 90% of the polyclonal immunoglobulins are in the form of monomers or dimers and less than 5% in the form of polymers, and wherein the immunoglobulin concentration in the composition is above 160 g/L and the pH is in the range from 5.2 to 5.9. The invention further relates to a liquid composition for use in medical treatment, to amino acids for formulating a highly concentrated polyclonal immunoglobulins as well as a method of formulating.
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公开(公告)号：US20220233692A1
公开(公告)日：2022-07-28
申请号：US17519141
申请日：2021-11-04
申请人： OCTAPHARMA AG
发明人： Karin Ahrer , Waltraud Kaar , Ulrich Roessl
IPC分类号： A61K39/395 , A61K47/18 , A61K9/00 , A61K9/08 , A61K47/22
摘要： The present invention relates to a liquid composition comprising polyclonal immunoglobulins, at least one viscosity modulating amino acid, selected from arginine and histidine, and at least one stabilising amino acid, selected from glycine and proline, wherein more than 90% of the polyclonal immunoglobulins are in the form of monomers or dimers and less than 5% in the form of polymers, and wherein the immunoglobulin concentration in the composition is above 160 g/L and the pH is in the range from 5.2 to 5.9. The invention further relates to a liquid composition for use in medical treatment, to amino acids for formulating a highly concentrated polyclonal immunoglobulins as well as a method of formulating.
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公开(公告)号：US20190125868A1
公开(公告)日：2019-05-02
申请号：US16308356
申请日：2017-06-12
申请人： OCTAPHARMA AG
发明人： Karin Ahrer , Waltraud Kaar , Ulrich Roessl
IPC分类号： A61K39/395 , A61K47/22 , A61K47/18
摘要： The present invention relates to a liquid composition comprising polyclonal immunoglobulins, at least one viscosity modulating amino acid, selected from arginine and histidine, and at least one stabilising amino acid, selected from glycine and proline, wherein more than 90% of the polyclonal immunoglobulins are in the form of monomers or dimers and less than 5% in the form of polymers, and wherein the immunoglobulin concentration in the composition is above 160 g/L and the pH is in the range from 5.2 to 5.9. The invention further relates to a liquid composition for use in medical treatment, to amino acids for formulating a highly concentrated polyclonal immunoglobulins as well as a method of formulating.
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