公开(公告)号：US20220331300A1

公开(公告)日：2022-10-20

申请号：US17596101

申请日：2020-06-03

Applicant: OITA UNIVERSITY INSTITUTE OF ADVANCED MEDICINE, INC.

Inventor： Shigeru MATSUOKA ,  Akira KATOH ,  Tadashi MISHINA ,  Kentaro YAMADA ,  Atsushi YOSHIMORI ,  Toshimasa ISHIZAKI ,  Akira NISHIZONO ,  Hiroyuki KOUJI

IPC: A61K31/439 ,  A61P31/14

Abstract: The present disclosure provides compounds useful in the treatment and prevention of rabies. The present disclosure provides compounds represented by formula XXIF or XXIB [in the formulas, R1, R2A, R2B, R3, and R4 are as defined in the specification], solvates or pharmaceutically acceptable salts thereof, the use of these compounds, solvates or pharmaceutically acceptable salts thereof to treat or prevent rabies, pharmaceutical compositions including these compounds, solvates or pharmaceutically acceptable salts thereof, and a method for treating and preventing rabies using the same.