公开(公告)号：US20240269165A1

公开(公告)日：2024-08-15

申请号：US18567479

申请日：2022-05-31

Applicant: Osaka University

Inventor： Shoichi Shimada ,  Yoshihisa Koyama ,  Makoto Kondo ,  Noriyoshi Usui ,  Hikaru Kobayashi ,  Yuki Kobayashi

IPC: A61K33/00 ,  A61K9/14 ,  A61P1/16 ,  A61P1/18 ,  A61P21/00

CPC classification number: A61K33/00 ,  A61K9/14 ,  A61P1/16 ,  A61P1/18 ,  A61P21/00

Abstract: An object is to provide a pharmaceutical or the like that can prevent or treat non-alcoholic fatty liver disease, pain associated with inactivity, or acute pancreatitis. [Solving Means] When silicon small particles are orally administered or placed on a skin or a mucous membrane, non-alcoholic fatty liver disease, pain associated with inactivity, and acute pancreatitis can be prevented or treated. The silicon small particles are particles each of which generates hydrogen when brought into contact with an aqueous solution having a pH of 7 or more. Provided is a preventive or therapeutic agent, pharmaceutical composition, medical device, food, or beverage comprising the silicon small particles for non-alcoholic fatty liver disease, pain associated with inactivity, or acute pancreatitis. The silicon small particles are suitably silicon fine particles and/or aggregates of the silicon fine particles.

公开(公告)号：US11446290B2

公开(公告)日：2022-09-20

申请号：US16626062

申请日：2018-06-27

Applicant: OSAKA UNIVERSITY

Inventor： Shoichi Shimada ,  Yukiko Yamamoto ,  Makoto Kondo

IPC: A61K31/4545 ,  A61P25/04

Abstract: The present invention provides a drug for preventing or treating chronic pain and a method for preventing or treating chronic pain. A pharmaceutical composition comprising a serotonin-3 receptor agonist such as a compound represented by the following formula (I): [wherein: m is an integer of 1 to 4; and R1 is each independently selected from the group consisting of a hydrogen atom, a halogen atom, a methyl group optionally substituted with 1 to 3 halogen atom(s), a methoxy group optionally substituted with 1 to 3 halogen atom(s), and a methylthio group optionally substituted with 1 to 3 halogen atom(s)] or a pharmaceutically acceptable salt thereof is useful for preventing or treating chronic pain. The above pharmaceutical composition is also useful for preventing or treating acute pain. Further, the present invention provides a method for screening a compound for preventing or treating chronic pain, the method comprising measuring a serotonin-3 receptor agonist activity.