公开(公告)号：US20220378943A1

公开(公告)日：2022-12-01

申请号：US17775780

申请日：2020-11-12

Applicant: OSAKA UNIVERSITY

Inventor： Seiji TAKASHIMA ,  Ken MATSUOKA ,  Yoshihiro ASANO ,  Osamu TSUKAMOTO ,  Hidetaka KIOKA

IPC: A61K48/00 ,  A61K35/76 ,  C12N15/63 ,  A61P9/04

Abstract: The object of the present invention is to provide a polynucleotide which can be inserted into an expression vector and can enhance the transcriptional activity of a predetermined promoter under heart failure.
The object is achieved by an enhancer polynucleotide comprising a polynucleotide consisting of a sequence having 80% or more identity with a sequence represented by SEQ ID NO: 1, or a polynucleotide consisting of a sequence having 80% or more identity with a sequence represented by SEQ ID NO: 2, wherein the enhancer polynucleotide responds to heart failure (where the enhancer polynucleotide excludes a polynucleotide having the same sequence as a sequence represented by SEQ ID NO: 13 and a polynucleotide having the same sequence as a sequence represented by SEQ ID NO: 12).