公开(公告)号：US20210145814A1

公开(公告)日：2021-05-20

申请号：US16626062

申请日：2018-06-27

Applicant: OSAKA UNIVERSITY

Inventor： Shoichi SHIMADA ,  Yukiko YAMAMOTO ,  Makoto KONDO

IPC: A61K31/4545 ,  A61P25/04

Abstract: The present invention provides a drug for preventing or treating chronic pain and a method for preventing or treating chronic pain. A pharmaceutical composition comprising a serotonin-3 receptor agonist such as a compound represented by the following formula (I): [wherein: m is an integer of 1 to 4; and R1 is each independently selected from the group consisting of a hydrogen atom, a halogen atom, a methyl group optionally substituted with 1 to 3 halogen atom(s), a methoxy group optionally substituted with 1 to 3 halogen atom(s), and a methylthio group optionally substituted with 1 to 3 halogen atom(s)] or a pharmaceutically acceptable salt thereof is useful for preventing or treating chronic pain. The above pharmaceutical composition is also useful for preventing or treating acute pain. Further, the present invention provides a method for screening a compound for preventing or treating chronic pain, the method comprising measuring a serotonin-3 receptor agonist activity.

公开(公告)号：US20210145865A1

公开(公告)日：2021-05-20

申请号：US17113886

申请日：2020-12-07

Applicant: OSAKA UNIVERSITY

Inventor： Shoichi SHIMADA ,  Yoshihisa KOYAMA ,  Makoto KONDO ,  Noriyoshi USUI ,  Kazuya OHATA ,  Hidenori INOHARA ,  Hikaru KOBAYASHI ,  Yuki KOBAYASHI

IPC: A61K33/00 ,  A61P3/10 ,  A61P9/10 ,  A61P25/28 ,  A61P25/16 ,  A61P25/24 ,  A61P1/16 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P27/16

Abstract: An object is to provide a pharmaceutical or the like that can prevent or treat an oxidative stress-induced disease. Provided is a preventive or therapeutic agent for an oxidative stress-induced disease, pharmaceutical composition, medical device, hygienic product, food, or beverage containing silicon small particles. When the silicon small particles are orally administered or placed on a skin or a mucous membrane, the oxidative stress-induced disease can be prevented or treated. The oxidative stress-induced disease is an inflammatory disease, depression, or the like, and an excellent preventive and therapeutic effect thereon is obtained.