公开(公告)号：US20190045759A1

公开(公告)日：2019-02-14

申请号：US16058568

申请日：2018-08-08

Applicant: OSAKA UNIVERSITY

Inventor： Yoko FUKUSHIMA ,  Kohji NISHIDA ,  Toru NAKANO

IPC: A01K67/027 ,  A61K49/00

Abstract: Provided are a non-human model animal of a retinal vascular disease that can favorably show symptoms similar to those of human retinal vascular diseases such as human diabetic retinopathy, and a method for producing the non-human model animal. In particular, provided are a non-human model animal that is suitable for establishing a method for treating, preventing, or diagnosing retinal edema, which causes highly impaired vision, and a method for producing the non-human model animal. A method for screening a drug for treating and preventing a retinal vascular disease, the method using a non-human model animal, is provided. Provided are a non-human model animal of a retinal vascular disease in which constitutively active Akt is expressed, a method for producing a non-human model animal of a retinal vascular disease in which constitutively active Akt is expressed, and a method for screening a drug for treating or preventing a retinal vascular disease.

公开(公告)号：US20240274295A1

公开(公告)日：2024-08-15

申请号：US18566168

申请日：2022-05-31

Applicant: OSAKA UNIVERSITY

Inventor： Yoko FUKUSHIMA ,  Kohji NISHIDA ,  Ryosuke KOJIMA ,  Yasushi OKUNO

IPC: G16H50/30 ,  G16H20/00

CPC classification number: G16H50/30 ,  G16H20/00

Abstract: There are provided a highly versatile method for screening for retinopathy of prematurity, a screening apparatus, and a trained model that are capable of accurately predict the progression of retinopathy of prematurity at appropriate timing. There is provided a method for screening for retinopathy of prematurity to predict the progression of retinopathy of prematurity, the method including a treatment determination step of determining whether or not treatment is indicated for retinopathy of prematurity after a predetermined number of days after birth based on premature infant information including postnatal time-series data on weight, height, and vital signs of a premature infant whose gestational age is less than a predetermined week.