公开(公告)号：US20230029594A1

公开(公告)日：2023-02-02

申请号：US17788524

申请日：2020-12-23

Applicant: OSAKA UNIVERSITY ,  INNATE CELL THERAPY INC.

Inventor： Shizuo AKIRA ,  JOSE CALDEZ MATIAS ,  Nobuo SAKAGUCHI

IPC: C12Q1/02 ,  A61P1/16 ,  C12N15/113 ,  C07K16/40

Abstract: The present invention provides a body fat reducing agent comprising a Regnase-1 inhibitor as an active ingredient, and a method for screening for a substance capable of reducing body fat, the method comprising selecting a substance capable of inhibiting the expression of Regnase-1 or a substance capable of inhibiting the function of Regnase-1. The body fat reducing agent of the present invention is useful for improving metabolic syndrome, and for preventing and/or treating fatty liver disease, including nonalcoholic steatohepatitis (NASH). The screening method of the present invention can be used to identify a useful substance capable of reducing body fat.