公开(公告)号：US20180333434A1

公开(公告)日：2018-11-22

申请号：US15970945

申请日：2018-05-04

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Maria Chiara Bonini ,  Attilio Bondanza

IPC: A61K35/17 ,  G01N33/68 ,  G01N33/569 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K48/0091 ,  A61K2039/5156 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2501/2302 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2506/11 ,  C12N2510/00 ,  G01N33/56972 ,  G01N33/6863 ,  Y02A50/412 ,  Y02A50/58

Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.

公开(公告)号：US11597755B2

公开(公告)日：2023-03-07

申请号：US16605561

申请日：2018-04-24

Applicant: Ospedale San Raffaele S.r.l. ,  Fondazione Centro San Raffaele

Inventor： Maria Chiara Bonini ,  Eliana Ruggiero ,  Zulma Irene Magnani ,  Luca Aldo Edoardo Vago ,  Attilio Bondanza ,  Fabio Ciceri

IPC: C07K14/725 ,  A61P35/00 ,  A61K35/17 ,  C07K14/47 ,  C12N5/0783 ,  A61K38/00

Abstract: TCR AND PEPTIDES A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).

公开(公告)号：US09974808B2

公开(公告)日：2018-05-22

申请号：US14660484

申请日：2015-03-17

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Maria Chiara Bonini ,  Attilio Bondanza

IPC: A61K48/00 ,  A61K35/17 ,  C12N5/0783 ,  G01N33/569 ,  G01N33/68 ,  A61K39/00

CPC classification number: A61K35/17 ,  A61K48/0091 ,  A61K2039/5156 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2501/2302 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2506/11 ,  C12N2510/00 ,  G01N33/56972 ,  G01N33/6863 ,  Y02A50/412 ,  Y02A50/58

Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.