公开(公告)号：US20230181719A1

公开(公告)日：2023-06-15

申请号：US17912765

申请日：2021-03-19

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Flavio CURNIS ,  Angelo CORTI ,  Andrès J. M. FERRERI

IPC: A61K39/215 ,  A61P31/14

CPC classification number: A61K39/215 ,  A61P31/14 ,  A61K2039/572

Abstract: The present invention relates to a conjugate comprising a first peptide of sequence CNGRCG (SEQ ID NO: 1) linked to the N-terminus of a protein and a compound X linked to the N-terminus of said peptide and to related medical uses.

公开(公告)号：US20220402980A1

公开(公告)日：2022-12-22

申请号：US17777228

申请日：2020-11-16

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Flavio CURNIS ,  Angelo CORTI ,  Giovanna MUSCO ,  Michela GHITTI ,  Francesca NARDELLI ,  Alessandro GORI

IPC: C07K14/47 ,  A61K49/00 ,  A61K47/64 ,  A61K51/08

Abstract: The present invention refers to chromogranin A-derived peptides that are potent dual ligands for integrins αvβ6 and avβ8, their therapeutic and diagnostic uses and relative compositions.