公开(公告)号：US20230134843A1

公开(公告)日：2023-05-04

申请号：US17910971

申请日：2021-03-11

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Giulio FERRARI ,  Paolo RAMA

IPC: A61K31/675 ,  A61K45/06 ,  A61P43/00

Abstract: The present invention refers to an inhibitor of substance P and/or of its receptor for use in the treatment and/or prevention of stem cell deficiency. Preferably the inhibitor is an NK1 antagonist. Preferably the stem cell deficiency is a corneal epithelial stem cell deficiency. The invention also refers to pharmaceutical compositions containing the inhibitor for use in the treatment and/or prevention of stem cell deficiency.

公开(公告)号：US20210015834A1

公开(公告)日：2021-01-21

申请号：US16968628

申请日：2019-02-26

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Paolo RAMA ,  Giulio FERRARI

IPC: A61K31/675 ,  A61P27/02

Abstract: The invention relates to compounds, in particular NK-1 antagonists, for use in the treatment of ocular sensitivity and/or ocular pain.