公开(公告)号：US20180305432A1

公开(公告)日：2018-10-25

申请号：US15763419

申请日：2016-10-03

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE CENTRO SAN RAFFAELE

Inventor： Giulia CASORATI ,  Paolo DELLABONA ,  Claudia DE LALLA ,  Claudio GARAVAGLIA ,  Michela CONSONNI

IPC: C07K14/725 ,  A61K39/00 ,  A61P35/02

CPC classification number: C07K14/7051 ,  A61K39/0011 ,  A61K2039/5156 ,  A61P35/02

Abstract: The present invention relates to a TCR or functional variant thereof having antigenic specificity for CD1c molecules associated with a self-lipid, preferably (mLPA) or derivative thereof, to relative polypeptide, protein, nucleic acid, recombinant expression vector, host cell, population of cells, antibody and pharmaceutical composition. The present invention also relates to the uses of said TCR and relative products, in particular for use in the treatment and/or prevention of an hematological disorder.