公开(公告)号：US20220213030A1

公开(公告)日：2022-07-07

申请号：US17599694

申请日：2020-04-01

申请人： OSPEDALE SAN RAFFAELE SRL

发明人： Gianvito MARTINO ,  Luca MUZIO ,  Nilo RIVA ,  Davide GORNATI ,  Pierfausto SENECI ,  Simona Carmen ELEUTERI

IPC分类号： C07C281/18 ,  A61P25/28 ,  C07C277/08 ,  C07D295/192 ,  C07C311/08 ,  C07C311/21 ,  C07D233/88

摘要： The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.