公开(公告)号：US20250152560A1

公开(公告)日：2025-05-15

申请号：US18838130

申请日：2023-02-13

Applicant: OnKure, Inc. ,  Array BioPharma Inc.

Inventor： Anthony D. Piscopio ,  Patrice Anne Lee ,  James Winkler ,  Richard D. Woessner

IPC: A61K31/429 ,  A61K31/4184 ,  A61K31/506 ,  A61P35/00

Abstract: A method of treating cancer in a subject in need thereof, wherein the method comprises administration of therapeutically effective amounts of OKI-179 and binimetinib or a pharmaceutically acceptable salt thereof, or administration of therapeutically effective amounts of OKI-179, binimetinib or a pharmaceutically acceptable salt thereof, and encorafenib or a pharmaceutically acceptable salt thereof according to the dosing schedules described herein.