公开(公告)号：US20210161991A1

公开(公告)日：2021-06-03

申请号：US17069300

申请日：2020-10-13

申请人： OncoImmune, Inc.

发明人： Yang LIU ,  Yin WANG ,  Yan LIU ,  Sami N. MALEK ,  Pan ZHENG

IPC分类号： A61K38/07 ,  A61K31/395 ,  A61K31/498 ,  A61K31/565 ,  A61K45/06 ,  A61K31/00 ,  A61K31/4355

摘要： The present invention relates to treating a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.