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公开(公告)号:US20040091458A1
公开(公告)日:2004-05-13
申请号:US10431580
申请日:2003-05-08
IPC分类号: A61K048/00 , A61K031/485
CPC分类号: A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要: The present invention provides a method for reducing pain associated with neoplasms in a mammal, comprising administering an effective amount of one or more oncolytic viruses. Preferably, the mammal also receives an analgesic, and the amount of analgesic required by the mammal is reduced when the oncolytic virus is administered. The oncolytic virus is preferably reovirus. The mammal may be additionally subject to other therapies, such as chemotherapy, immunotherapy, hormonal and/or radiation therapy.
摘要翻译: 本发明提供了减少与哺乳动物赘生物相关的疼痛的方法,包括施用有效量的一种或多种溶瘤病毒。 优选地,哺乳动物还接受止痛剂,并且当施用溶瘤病毒时,哺乳动物所需的止痛剂的量减少。 溶瘤病毒优选为呼肠孤病毒。 哺乳动物可以另外进行其他治疗,例如化学疗法,免疫治疗,激素和/或放射治疗。
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2.
公开(公告)号:US20040091463A1
公开(公告)日:2004-05-13
申请号:US10431579
申请日:2003-05-08
IPC分类号: A61K051/00 , A61K048/00
CPC分类号: A61K41/0038 , A61K35/765 , C12N2720/12232
摘要: The present invention relates to methods of sensitizing neoplastic cells to irradiation by using oncolytic viruses, particularly reoviruses. Also provided are methods of treating or ameliorating a tumor with a combination of oncolytic viruses and radiotherapy.
摘要翻译: 本发明涉及通过使用溶瘤病毒特别是呼肠孤病毒使肿瘤细胞增殖的方法。 还提供了用溶瘤病毒和放射治疗组合治疗或改善肿瘤的方法。
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