公开(公告)号：US11807626B2

公开(公告)日：2023-11-07

申请号：US17238121

申请日：2021-04-22

申请人： Opna Bio SA

发明人： Songyuan Shi ,  John Buell ,  Zuojun Guo ,  Cuong Ly ,  Wayne Spevak ,  Mark Vander Wal ,  Jack Walleshauser ,  Chao Zhang ,  Jiazhong Zhang

IPC分类号： C07D401/14 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/08 ,  C07D491/107

CPC分类号： C07D401/14 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/08 ,  C07D491/107

摘要： Disclosed are compounds of Formula I:






or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R1, R2, R3, A, E, L, and G are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.

公开(公告)号：US20240174640A1

公开(公告)日：2024-05-30

申请号：US18383523

申请日：2023-10-25

申请人： Opna Bio SA

发明人： Songyuan Shi ,  John Buell ,  Zuojun Guo ,  Cuong LY ,  Wayne Spevak ,  Mark Vander Wal ,  Jack Walleshauser ,  Chao Zhang ,  Jiazhong Zhang

IPC分类号： C07D401/14 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/08 ,  C07D491/107

CPC分类号： C07D401/14 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/08 ,  C07D491/107

摘要： Disclosed are compounds of Formula I:






or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R1, R2, R3, A, E, L, and G are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.