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公开(公告)号:US10786470B2
公开(公告)日:2020-09-29
申请号:US16339664
申请日:2017-09-29
发明人: Victor A. Levin , Noymi Yam , Alexander Vakoula
IPC分类号: A61K31/197 , A61K9/00 , A61K47/26 , A61P43/00 , A61P35/00 , C07C229/00 , A61P25/00
摘要: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the eflornithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.
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公开(公告)号:US11439612B2
公开(公告)日:2022-09-13
申请号:US17002117
申请日:2020-08-25
发明人: Victor A. Levin , Noymi Yam , Alexander Vakoula
IPC分类号: A61K31/197 , A61K47/26 , A61P43/00 , A61P35/00 , C07C229/00 , A61K9/00 , A61P25/00
摘要: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the elformithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.
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