公开(公告)号：US12104154B2

公开(公告)日：2024-10-01

申请号：US17666341

申请日：2022-02-07

申请人： Osaka University

发明人： Satoshi Obika ,  Reiko Waki ,  Takao Inoue ,  Tokuyuki Yoshida ,  Kunihiko Morihiro ,  Yuya Kasahara ,  Atsushi Mikami

IPC分类号： C12N15/113 ,  A61K31/7115 ,  A61K31/712

CPC分类号： C12N15/113 ,  A61K31/7115 ,  A61K31/712

摘要： The present invention aims to provide an antisense oligonucleic acid with reduced hepatotoxicity. The antisense oligonucleic acid according to the present invention is characterized in that it has a base length of not less than 7 nt and not more than 30 nt, wherein nucleic acid residues of not less than 1 nt and not more than 5 nt respectively from the both terminals are 2′,4′-bridged nucleic acids, 2′,4′-non-bridged nucleic acid residue(s) is(are) present between the above-mentioned both terminals, and one or more bases in the nucleic acid residue(s) of the above-mentioned 2′,4′-non-bridged nucleic acid residue(s) is/are modified.

公开(公告)号：US11261440B2

公开(公告)日：2022-03-01

申请号：US16487762

申请日：2018-02-20

申请人： Osaka University

发明人： Satoshi Obika ,  Reiko Waki ,  Takao Inoue ,  Tokuyuki Yoshida ,  Kunihiko Morihiro ,  Yuya Kasahara ,  Atsushi Mikami

IPC分类号： C12N15/113 ,  A61K31/7115 ,  A61K31/712

摘要： The present invention aims to provide an antisense oligonucleic acid with reduced hepatotoxicity. The antisense oligonucleic acid according to the present invention is characterized in that it has a base length of not less than 7 nt and not more than 30 nt, wherein nucleic acid residues of not less than 1 nt and not more than 5 nt respectively from the both terminals are 2′,4′-bridged nucleic acids, 2′,4′-non-bridged nucleic acid residue(s) is(are) present between the above-mentioned both terminals, and one or more bases in the nucleic acid residue(s) of the above-mentioned 2′,4′-non-bridged nucleic acid residue(s) is/are modified.