公开(公告)号：US20190271708A1

公开(公告)日：2019-09-05

申请号：US16302235

申请日：2017-05-17

申请人： Osaka University ,  Shiseido Company, Ltd.

发明人： Yoshitaka Isaka ,  Tomonori Kimura ,  Keiko Yasuda ,  Kenji Hamase ,  Masashi Mita

IPC分类号： G01N33/68

摘要： The purpose of the present invention is to provide: a blood sample analysis method for determining diabetes complications in subjects with kidney damage on the basis of D- and L-amino acid content, from a blood sample; a method for examining diabetes complications; and a sample analysis system that outputs pathological information about diabetes complications. The purpose of this invention is achieved by using at least one amino acid selected from the group consisting of D-aspartic acid, D-proline, L-glutamine, and L-isoleucine, in order to determine diabetes complications.

公开(公告)号：US20190317106A1

公开(公告)日：2019-10-17

申请号：US16302226

申请日：2017-05-17

申请人： Osaka University

发明人： Yoshitaka Isaka ,  Tomonori Kimura ,  Keiko Yasuda ,  Kenji Hamase ,  Masashi Mita

IPC分类号： G01N33/68 ,  G01N33/72

摘要： The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.

公开(公告)号：US11099191B2

公开(公告)日：2021-08-24

申请号：US16302226

申请日：2017-05-17

申请人： Osaka University ,  Kagami Inc.

发明人： Yoshitaka Isaka ,  Tomonori Kimura ,  Keiko Yasuda ,  Kenji Hamase ,  Masashi Mita

IPC分类号： G01N33/68 ,  G01N33/72

摘要： The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.